Table of Content

25 August 2023, Volume 15 Issue 4 Previous Issue    Next Issue

Select

Expert consensus on body constitution characteristics and nursing of children in traditional Chinese medicineBody Constitution WANG Qi, WANG Xuefeng, ZHAO Xia, LI Min 2023, 15 (4):  277-282.  Abstract ( 275 )   PDF (857KB) ( 757 )   Save Expert consensus on body constitution characteristics and nursing of children in traditional Chinese medicineBody Constitution Research Committee of World Federation of Chinese Medicine Societies Related Articles | Metrics

Select

Risk factors influencing the prognosis of tic disorders in Chinese children: a systematic review GUO Zhiyi, YANG Kejia, LEI Jing, ZENG Yongjian, GUO Zhidong, SUN Xiangjuan. 2023, 15 (4):  283-290.  Abstract ( 125 )   PDF (2273KB) ( 244 )   Save ObjectiveTo systematically evaluate the risk factors influencing the prognosis of tic disorders(TD) in Chinese children.MethodsThe observational studies on the factors affecting the prognosis of children with TD were retrieved in electronic Chinese and English databases from their inception to April 2022, including PubMed, EMbase, The Cochrane Library, Web of Science, CBM, VIP, Wanfang and CNKI. Two researchers independently screened the literature, extracted the data, and evaluated the included literatures using NOS scale. RevMan 5.4 software was used for meta-analysis.ResultsA total of 3 572 articles were retrieved, and 10 articles were finally included, including 2 case-control studies and 8 cohort studies, with a total of 1 699 TD children. The results of Meta-analysis showed that family history of mental and neurological diseases［OR=3.17,95%CI(1.51,6.66)］, comorbidity［OR=2.55,95%CI(1.68,3.87)］, frequency of disease recurrence ［OR=3.65,95%CI(2.06,6.48)］, disease severity ［OR=1.52,95%CI(1.19,1.94)］, repeated respiratory infection ［OR=1.33,95%CI(1.22,1.44)］, and family environment［OR=3.00,95%CI(1.50,5.99)］ were risk factors influencing the prognosis of tic disorders in Chinese children.ConclusionFamily history of mental and neurological disorders, comorbidities, frequency of TD recurrence, severity of disease, recurrent respiratory infection and family environment are associated with poor prognosis of tic disorders in Chinese children. Related Articles | Metrics

Select

Study on the clinical efficacy of Changyu Dongzhi prescription in the treatment of children with tic disorder WANG Zhuang, WANG Yongji, WEI Lina, KONG Yibu, WANG Xiran. 2023, 15 (4):  290-294.  Abstract ( 111 )   PDF (853KB) ( 149 )   Save ObjectiveTo scientifically evaluate the clinical efficacy of Changyu Dongzhi prescription， which is based on a treatment method that simultaneously treats wind and fire， in the treatment of children with tic disorder （syndrome of liver wind hyperactivity）， and to provide evidence-based evidence for clinical application.MethodsA total of 100 children with tic disorder （syndrome of liver wind hyperactivity） were chosen, who were treated at the Children's Diagnosis and Treatment Center of Changchun University of Traditional Chinese Medicine Affiliated Hospital from September 2021 to December 2022, and they were randomly divided into two groups using a random number table method, with 50 children in each group. The experimental group was treated with Changyu Dongzhi prescription with modification, which was taken orally， while the control group was treated with clonidine transdermal patches for application. The treatment lasted for 3 months. The clinical efficacy， average course of disease， and improvement of symptoms between the two groups were compared.ResultsThe total effective rate of experimental group was 96.0%(48/50),higher than that of control group(84.0%,42/50),and there was statistical difference(P<0.05). In terms of YGTSS， traditional Chinese medicine syndrome score， disease course， and degree of symptom relief，the experimental group was better than the control group， with statistical differences （P<0.05）.ConclusionChangyu Dongzhi prescription can effectively alleviate the symptoms of tic disorder （syndrome of liver wind hyperactivity） and improve the therapeutic effect， which provides new ideas and plans for tic disorder， and is worthy of clinical promotion and application. Related Articles | Metrics

Select

Network pharmacological study on the mechanism of Acorus tatarinowii in the treatment of ADHD from phlegm theory HE Jingwei, LI Mengyao, LIANG Pengchen, ZHU Daqian, YU Jian. 2023, 15 (4):  295-301.  Abstract ( 90 )   PDF (1772KB) ( 144 )   Save ObjectiveFrom the basic theory of traditional Chinese medicine based on "differentiated treatment from phlegm theory", the key target and mechanism of Acorus tatarinowii in the treatment of ADHD were discussed by means of network pharmacology.MethodsThe effective active components and potential targets of Acorus tatarinowii and disease targets of ADHD were screened by traditional Chinese medicine system pharmacology database, analysis platform (TCMSP database) and Genecards database. The common targets were screened on the R software platform; the protein-protein interaction (PPI) network was constructed; the "drug-active ingredient-target-disease" relationship was constructed; the GO and KEGG signal pathways were analyzed; pymol was used to visualize the docking results.ResultsNine active components of Acorus tatarinowii and 99 intersection targets related to ADHD were screened out. Target proteins such as INS, AKT1, JUN, CASP3 and FOS were potential targets for intervention of ADHD by Acorus tatarinowii. The related targets involved multiple biological processes and molecular functions. The mechanism of Acorus tatarinowii in the treatment of ADHD was closely related to apoptosis-related pathways, inflammation-related pathways, lipid metabolic signal pathways, virus infection pathways and so on.ConclusionA variety of effective components of Acorus tatarinowii play a role through multiple signal pathways and different targets, reflecting the action mechanism and characteristics of multi-components, multi-targets, multi-links and multi-pathways of traditional Chinese medicine, which is helpful to explore the mechanism of Acorus tatarinowii in the treatment of ADHD. Related Articles | Metrics

Select

Progress in TCM treatment for childhood simple obesity SONG Qinli, ZHAO Jun, JIN Ying, YANG Chuwen, LU Xiaoye, ZHOU Fangyuan. 2023, 15 (4):  301-304.  Abstract ( 223 )   PDF (832KB) ( 244 )   Save With the development of social economy and the change of lifestyle, more and more children are overweight and obese. If the obese children are not treated in time, they will gradually develop obesity syndrome, which will lay the groundwork for hypertension, hyperlipidemia, diabetes and other diseases in adulthood, and also bring burden to the social economy and medical resources. Traditional Chinese medicine has its unique advantages in the treatment of simple obesity in children. This article reviews the research progress in the treatment of simple obesity in children from the aspects of etiology, pathogenesis, syndrome differentiation and internal and external treatment of traditional Chinese medicine. The syndrome differentiation of simple obesity generally follows "phlegm, deficiency and stasis". The main treatment methods are to strengthen spleen and supplement qi, remove dampness and eliminate phlegm, and activate qi and blood circulation to remove blood stasis. Single Chinese medicine, compound Chinese medicine and external treatment of Chinese medicine all play an important role in the treatment of simple obesity in children. Related Articles | Metrics

Select

Research status of the influence of prone position on sleep and organ functions in premature infants FU Caiyu, WANG Aiqiong, SA Rina. 2023, 15 (4):  305-309.  Abstract ( 96 )   PDF (860KB) ( 13 )   Save The sleep development of premature infants is a highly dynamic process, which is closely related to the function of heart, lung and brain as well as growth and development. Researches on prone position(PP) has attracted increasing attention in terms of its effects on pulmonary oxygenation, cardiopulmonary stability, cerebral blood perfusion, brain function, and digestion in preterm infants, which are highly relevant to changes in body position during PP and its effects on sleep. Although much research progress has been made in the effects of PP on sleep development and organ function of premature infants, there are still some controversial issues that need further research. This paper will start from the sleep and organ development characteristics of premature infants, and focus on the effects of PP on sleep, heart, lung, brain and digestion of premature infants. This paper mainly reviews the effects of PP on sleep of premature infants and the effects of PP on the relationship between sleep state and organ function of premature infants. Related Articles | Metrics

Select

Research progress in autoimmune encephalitis in children TANG Yongzai, QIAO Pei, WU Mei, WANG Chunyan, DONG Yan. 2023, 15 (4):  309-313.  Abstract ( 126 )   PDF (879KB) ( 68 )   Save In recent years, autoimmune encephalitis has been paid more and more attention to in central immune diseases. In 1960s, some scholars have found that patients with marginal damage were often complicated with tumor lesions of other systems. With the research deepened, paraneoplastic, non-paraneoplastic and infectious types have also been found. The pathogenesis of autoimmune encephalitis is unknown. The most common clinical classification of autoimmune encephalitis is based on different types of antireceptors, and different classifications have different clinical manifestations. For different clinical symptoms, the treatment for autoimmune encephalitis includes symptomatic treatment and immunotherapy. This article will summarize the above aspects in order to provide some reference for clinicians' understanding of the disease. Related Articles | Metrics

Select

Research progress in the genetics of febrile seizures in children JIANG Yanli, YAN Lulu, XIE Min, ZHUANG Danyan, LI Haibo. 2023, 15 (4):  314-318.  Abstract ( 89 )   PDF (890KB) ( 81 )   Save Febrile seizures（FS） is one of the most common diseases in infancy and early childhood, and some children with FS progress to epilepsy in the later stage of the disease. At present, the pathogenesis of FS is not clear. In recent years, studies have shown that FS has a significant familial genetic tendency, and their pathogenesis is related to mutations in sodium channel genes, potassium channel genes, chloride channel genes, cytokine genes, proline-rich transmembrane protein 2 gene, and synaptic fusion protein 1B gene.  Related Articles | Metrics

Select

Diagnosis and treatment strategies of short stature based on the theory of integrated traditional Chinese and western medicine YU Feng, XU Huifu, CHEN Zhixin. 2023, 15 (4):  319-323.  Abstract ( 91 )   PDF (1052KB) ( 320 )   Save With the development and progress of social economy and culture, more and more parents are paying attention to children's short stature. Especially, with the increasing demand for external factors in various industries and mate selection, the issue of children's growth and development has become a new focus of children's diseases in the post-pandemic era. Although the treatment methods with western medicine have rapid and significant effect, the origins are not long enough and the long-term risks are unknown; moreover, the clinical physique of children is constantly changing, making it impossible to fully suit indications. Traditional Chinese medicine, as an important component of China's traditional culture, can regulate children's physical fitness and promote growth and development, so the combination of traditional Chinese medicine with western medicine helps to improve the efficiency and quality of diagnosis and treatment for short stature. The integration of traditional Chinese and western medicine is an inevitable choice for the development of socialism with Chinese characteristics. This article starts with the diagnosis and treatment characteristics of traditional Chinese and western medicine, analyzes the advantages and disadvantages of existing diagnosis and treatment methods, andsummarizes five common clinical types of short stature, including: growth hormone deficiency, central precocious puberty, constitutional delayed puberty, small for gestational age, and idiopathic short stature. Based on the integration of traditional Chinese with western medicine, corresponding strategies are briefly discussed. Related Articles | Metrics

Select

A case of neuroblastoma complicated with heart failure in children MENG Ying. 2023, 15 (4):  324-328.  Abstract ( 54 )   PDF (851KB) ( 478 )   Save One case of neuroblastoma complicated with heart failure in children is reported, and the possible cause was studied. The child patient is 3 years and 7 months old, the onset is occult and anorexia is the first symptom. After abdominal imaging and postoperative histopathological examination, it is diagnosed as neuroblastoma. In the 4 months of treatment, the following chemotherapy regimens have been used in turn: cyclophosphamide combined with irinotecan, etoposide combined with cisplatin， and then etoposide combined with nedaplatin. After 5 cycles of chemotherapy, the child has some symptoms of acute heart failure, including dyspnea, forced sitting position, pallor, cyanosis and irritation. Clinically there have been few reports on heart failure after chemotherapy for neuroblastoma, so we should be alert and pay attention to the toxic effect of chemotherapy medicines on heart, performing related examinations at an early stage in order to improve heart function and the prognosis. Related Articles | Metrics

Select

Application of group game articulation training in rehabilitation of children with articulation disorder after cerebral palsy and its influence on oral motor function and language function YANG Xiaoxiao, ZHENG Haiyu, XIA Xiaoni. 2023, 15 (4):  328-331.  Abstract ( 62 )   PDF (822KB) ( 70 )   Save ObjectiveTo study the effects of game articulation training on oral motor function and language function in children with articulation disorder after cerebral palsy.MethodsNinety-eight children with articulation disorder after cerebral palsy were selected, who were admitted to the Pediatric Department of the New District Hospital of the First Affiliated Hospital of Henan University of Science and Technology from January 2021 to October 2022, and they were divided into the observation group and the control group with 49 cases in each group according to random number table method. The control group was given routine one-to-one language training, and the observation group was given group game articulation training. The improvement in articulation disorder, oral motor function and language function were compared between the two groups.ResultsThe improvement in motor function of tongue, lip and jaw in the observation group were higher than that in the control group, and the difference was statistically significant (P<0.05). The improvement in expression ability, operation ability and understanding ability of the observation group were higher than that of the control group, and the difference was statistically significant(P<0.05). The treatment effect of group game articulation training was better than that of routine one-to-one language training. ConclusionGroup game articulation training has a definite effect on children with articulation disorder after cerebral palsy, which can effectively improve the oral motor function, relieve articulation disorder and strengthen language function Related Articles | Metrics

Select

Effects of sling exercise therapy combined with international college of biomechanics on the motor function and daily living activity ability of children with cerebral palsy BI Fengli, GUO Meng, JIA Zhuting, ZHAO Cui, ZHANG Limei, LI Wei. 2023, 15 (4):  332-335.  Abstract ( 71 )   PDF (828KB) ( 100 )   Save ObjectiveTo observe the effects of sling exercise therapy(SET) combined with international college of biomechanics(ICB) on the motor function and daily living activity ability of children with cerebral palsy.MethodsTotally 52 children with spastic hemiplegia of cerebral palsy were selected and randomly divided into a control group(n=26) and an experimental group(n=26).Both groups were given conventional rehabilitation therapy and ICB; in addition, the experimental group was given sling exercise therapy. The treatment lasted for 3 months for both groups. They were assessed with Gross Motor Function Measure (GMFM-88),Berg balance scale(BBS) and  Functional Independence Measure Children's Edition (WeeFIM) before and after treatment.ResultsAfter treatment there was significant improvement in both groups with regard to the scores of GMFM,BBS and WeeFIM. The improvement was of statistical significance(P<0.05). ConclusionThe sling exercise therapy combined with ICB can effectively improve the motor function and daily living activity ability of children with spastic hemiplegia of cerebral palsy. Related Articles | Metrics

Select

Treatment for long-term repeated hyperthermia in children based on dialectical thinking of Zhongjing Lily disease GUO Yanrong, ZHAO Kun, ZHANG Yan, CHEN Xiaosong, SONG Guihua, YU Suping. 2023, 15 (4):  335-338.  Abstract ( 118 )   PDF (832KB) ( 171 )   Save This paper introduces the treatment experience in children with long-term repeated hyperpyrexia based on the dialectical thinking of Zhongjing Lily disease. The clinical manifestations of hypothalamus syndrome are various, mainly manifested as hyperpyrexia, overeating, abnormal water drinking, polyuria, and obesity, etc. However, the treatment for hypothalamus syndrome with long-term hyperpyrexia as the main manifestation is troublesome. Based on Zhongjing's dialectical thinking, combined with the characteristics of long-term hyperpyrexia, and inspired by Synopsis of the Golden Chamber: Lily Huhuo's Syndrome of Yin and Yang, the Third Treatment, and from the perspective of Lily disease, Professor Zhao Kun thinks that the pathogenesis is yin-yang imbalance, yin deficiency and internal heat, and mental loss. The treatment is to reconcile yin and yang, nourish yin and clear heat, and make calm, and he has made a self-made "Lily Antipyretic Decoction", which has a remarkable effect. Related Articles | Metrics

Select

A comparative study of three different height prediction methods in girls with precocious puberty of phlegm-dampness obstruction type treated by Jianpi Ziyin prescription LU Xiaoye, ZHAO Jun, JIN Ying, YANG Chuwen, SONG Qinli, ZHOU Fangyuan. 2023, 15 (4):  339-343.  Abstract ( 78 )   PDF (949KB) ( 72 )   Save ObjectiveTo compare three different height prediction methods［growth curve method, Bayley-Pinneau(B-P) method and new method］ in girls with precocious puberty of phlegm-dampness obstruction type after the treatment with Jianpi Ziyin prescription, and analyze their value in predicting adult height(PAH).MethodsForty precocious puberty girls with phlegm-dampness obstruction were chosen, who were treated in Pediatric Department of shanghai University of Traditional Chinese Medicine from Jan. 1,2005 to June 30,2016. Their mean age on visiting the hospital was 7.20±0.85 years old. Only Jianpi Ziyin prescription was used during the whole process of treatment. The treatment lasted for 2 years, and the girls' final height was followed up. Greulich-Pyle atlas method and estimated PAH method were used, and the three methods were used to predict adult height， which was compared with the final height.ResultsThe final height of the 40 girls was (164.46±4.66)cm. The PAH before treatment, at 1 year of treatment and when the drug was stopped was (156.35±5.24)cm,(157.11±5.42)cm and (159.74±4.37)cm by growth curve method; it was (161.84±7.40)cm，(163.18±7.46)cm and (165.83±5.95)cm by B-P method; it was (154.64±7.24)cm，(157.90±7.29)cm and (161.49±5.77)cm by new method. The comparison of PAH before treatment and when the drug was stopped among the groups showed statistical difference(P<0.05).Comparing the PAH at each treatment stage with the final height, there was no statistical difference in PAH by B-P method at more than one year of treatment (P>0.05). The PAH when the drug was stopped by growth curve method. B-P method and new method was all positively correlated with the final height(r=0.70,0.75,0.71),and the difference between final height and PAH was (4.72±3.48)cm, (-1.37±3.99)cm and (2.97±4.11)cm, with the 95%CI being 3.61 to 5.84, -2.64 to -0.90 and 1.66 to 4.29.ConclusionThe Bayley-Pinneau method is more suitable for predicting adult height of girls with precocious puberty of phlegm-dampness obstruction type treated by Jianpi Ziyin prescription. Related Articles | Metrics

Select

Treatment for children with allergic rhinitis of deficiency of lung and spleen qi from the perspective of nasal Xuan-Fu ZHANG Meng, XIE Bin, CHE Shuyan. 2023, 15 (4):  343-346.  Abstract ( 102 )   PDF (837KB) ( 148 )   Save Allergic rhinitis, as a common and frequently-occurring clinical disease in pediatrics, has gradually drawn the attention of experts and scholars, but the researches on it are mainly concerned with Zang-Fu syndrome differentiation. This article tries to study the etiology and pathogenesis and new treatment plans of allergic rhinitis based on microscopic Xuan-Fu combined with macroscopic Zang-Fu syndrome differentiation from the following aspects: the origin of nasal Xuan-Fu concept, the physiological features, the pathophysiological relationship with allergic rhinitis and the medication according to the association between the two. The Xuan-Fu blockage is the root cause of various diseases: the Zang-Fu blockage leads to fluid obstruction and defense-qi not being released, and the abnormal flowing of fluid and qi results in various diseases, which is the principal starting point and focus. It is hoped that the TCM Xuan-Fu theory will provide more points of thoughts for the researches in allergic rhinitis, and through establishing the association between nasal Xuan-Fu and western medicine pathways as well as targets, more lines of thinking and directions will be provided for the researches in the treatment of allergic rhinitis. Related Articles | Metrics

Select

Effect of Wenyang Tongluo acupuncture and moxibustion on spastic state of upper limb muscle group, limb motor function and EEG power in children with spastic cerebral palsy XI Mali, LIU Chunlei, WANG Paoqiu, LUO Wei, TAN Longze. 2023, 15 (4):  347-351.  Abstract ( 56 )   PDF (839KB) ( 83 )   Save ObjectiveTo investigate the effects of Wenyang Tongluo acupuncture and moxibustion combined with occupational therapy on spastic state of upper limb muscle group, limb motor function and EEG power in children with spastic cerebral palsy.MethodsA total of 113 children with spastic cerebral palsy admitted to our hospital from August 2020 to August 2022 were chosen and randomly divided into two groups. The 56 cases in the single group were given occupational therapy and 57 cases in the combination group were given combined Wenyang Tongluo acupuncture and moxibustion. The clinical efficacy, spastic state of upper limb muscle group, limb motor function and EEG power indexes of the two groups were compared.ResultsThe total effective rate of combination group (94.74%,54/57) was higher than that of single group (82.14%,46/56) (P<0.05). MAS scores of biceps brachialis, coracobrachialis and flexor carpi ulnar in combination group were lower than those in single group (P<0.05). UEFT, GMFM and WeeFIM scores in combination group were all higher than those in single group (P<0.05). The power of θ wave and α/SMR ratio in combination group was lower than that in single group, and the power of β wave was higher than that in single group (P<0.05).ConclusionWenyang Tongluo acupuncture and moxibustion combined with occupational therapy has good therapeutic effect, which can effectively improve the brain wave of children with spastic cerebral palsy, reduce muscle tension, relieve spastic state of upper limb muscle group, and promote the recovery of limb motor function. Related Articles | Metrics

Select

Clinical study on Xiaoer Dingchuan granules in treating viral pneumonia in children (Phlegm-heat blocking lung syndrome)  GAO Yuanyuan, WANG Xuefeng, ZHANG Xiuying, MENG Bin, E Mingxin, WANG Hui. 2023, 15 (4):  351-355.  Abstract ( 88 )   PDF (873KB) ( 121 )   Save ObjectiveTo evaluate the efficacy of Xiaoer Dingchuan granules on viral pneumonia in children (phlegm-heat blocking lung syndrome) and the safety of clinical application of Xiaoer Dingchuan granules.MethodsSixty children diagnosed with viral pneumonia in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine and the Hospital of Traditional Chinese Medicine of Manzhou Autonomous County from January 2023 to June 2023 were selected and divided into experimental group and control group by random number table method, with 30 children in each group. Based on the basic treatment and symptomatic treatment of budesonide aerosol inhalation in the control group, the experimental group was given corresponding doses of Xiaoer Dingchuan granules according to the age of children. The course of treatment was 7 days. At the end of treatment course, we observed (1) the total effective rate of the symptom improvement score of viral pneumonia in children; (2) total effective rate of improvement of TCM syndromes of viral pneumonia in children; (3) the efficacy and disappearance rate of single symptom treatment for viral pneumonia in children; (4) incidence of adverse reactions/events.ResultsA total of 3 cases were lost due to patient loss of follow-up or drug replacement. Among the 3 cases, 1 case was lost due to loss of follow-up in the observation group, 1 case was lost due to loss of follow-up in the control group, and 1 case was lost due to drug replacement in the control group. Finally, a total of 57 cases were included in the statistical analysis. After 7 days of treatment, the observation group was significantly better than the control group in the total effective rate of symptom improvement score in children's Viral pneumonia, the total effective rate of TCM syndrome improvement, the disappearance rate in single symptom treatment, and the total effective rate in cough, throat phlegm or sputum symptoms. The difference between the two groups was statistically significant (P<0.05);however, the difference between the two groups was not statistically significant(P>0.05) in the total effective rate in wheezing, fever or lung rales. In terms of adverse reactions/events, during the treatment period, there was 1 case of diarrhea event in the observation group, with an incidence rate of 3.45% (1/29). During the observation period, there was 1 case of diarrhea event and 2 cases of nausea and vomiting event in the control group, with an incidence rate of 10.71% (3/28) in the control group. There was no statistically significant difference in the incidence of adverse reactions/events between the two groups (P>0.05).ConclusionXiaoer Dingchuan granules can effectively improve the symptoms and TCM syndromes of viral pneumonia in children, and have a significant effect on the typical symptoms of viral pneumonia in children, such as wheezing, cough, phlegm or sputum in the throat, fever, pulmonary auscultation symptoms and disappearance rate; the incidence of adverse reactions is low, and the clinical application is safe. Related Articles | Metrics

Select

Clinical highlights in using pair medicines to treat children with precocious puberty based on syndrome differentiation CAI Qiang, ZHANG Xuerong. 2023, 15 (4):  356-358.  Abstract ( 64 )   PDF (1201KB) ( 157 )   Save Precocious puberty is a frequently-occurring and common disease in clinical pediatric endocrinology. TCM syndrome differentiation and treatment has obvious characteristics and advantages. Professor Zhang Xuerong has a lot of experience in the treatment of precocious puberty. Based on the overall concept and syndrome differentiation and treatment, the treatment is mainly by regulating the liver and kidney and nourishing yin and reducing fire, which is combined with soothing the liver and relieving depression, resolving phlegm and dispersing stagnation, and treating symptoms and causes together. Making good use of the pair medicines in the prescription and keeping simple and controlling complexity has remarkable curative effect. Related Articles | Metrics

Select

Data mining of medication rules for neurogenic frequent urination of kidney deficiency and dampness-heat type in children   Qin ManGONG Zehui 2023, 15 (4):  359-364.  Abstract ( 48 )   PDF (1201KB) ( 159 )   Save ObjectiveTo analyze the medication rules of Professor Qin Man in the treatment of neurogenic frequent urination of kidney deficiency and dampness-heat type in children.MethodsThe outpatient records from January 2021 to November 2022 were collected and input into Microsoft Excel 2016. SPSS Modeler 18.0 and SPSS Statistics 25 were used for data mining.ResultsA total of 77 prescriptions were included, including91 TCM  herbs. The drug properties were mainly cold, calm and warm, and the tastes were mainly sweet, bitter and spicy, and the drug channels were mainly lung, stomach and liver channels. Among them, 15 high-frequency drugs took into account many aspects of drug use, such as clearing heat and detoxifying and removing dampness. Twenty association rules of drugs and two clustering prescriptions were obtained after analysis.ConclusionProfessor Qin Man pays attention to clearing heat and dispelling dampness while protecting kidney qi in the treatment of children with neurotic frequency urination of kidney deficiency and dampness-heat type. Through the data mining of medical records prescription, the medication rules can be summarized comprehensively, which can provide certain reference ideas for the clinical diagnosis and treatment of this disease. Related Articles | Metrics

Select

Observation on the clinical efficacy of Jianer Zhuzhang paste in the treatment of spleen and kidney deficiency in short stature children SONG Yanling, KUANG Qi, WANG Xiaoming, CHEN Yuyan. 2023, 15 (4):  365-368.  Abstract ( 66 )   PDF (823KB) ( 77 )   Save ObjectiveTo observe the clinical effect of Jianer Zhuzhang paste in the treatment of spleen and kidney deficiency in short stature children.MethodsA total of 120 short stature children with spleen and kidney deficiency were selected， who were admitted to the Department of Pediatrics of Zhejiang Provincial Hospital of Traditional Chinese Medicine from March to May in 2020 and 2021， and they were divided into a treatment group and a control group by random number table method, with 60 cases in each group. Each group was divided into two subgroups according to age: 3-6 years old（n=30） and 7-11 years old（n=30）. Both groups were given lifestyle intervention for 6 months, and the treatment group was additionally treated with Jianer Zhuzhang paste for 2 months. After 2 months and 6 months, the clinical efficacy, height increase, bone age change and adverse reactions of the two groups were counted.ResultsIn the children aged 3 to 6 years，the total effective rate of the treatment group was 73.33%(22/30),higher than that of the control group(26.67%,8/30)(P<0.05). The height increase of the treatment group in 2 months and 6 months was greater than that of the control group (P<0.05). In the children aged 7 to 11 years, the total effective rate was 63.33%（19/30）, which was higher than that of the control group(20.00%,6/30) (P<0.05).The height increase had no statistical difference between the two groups after two months of treatment(P>0.05).The height increase in treatment group was greater than that in control group at 6 months of treatment, with statistical difference(P<0.05). There was no difference in bone age change between the two groups at 6 months of treatment(P>0.05).ConclusionJianer Zhuzhang paste can effectively improve the growth rate of children, has no adverse effect on bone age, and has good compliance in children and parents, which is worthy of clinical application. Related Articles | Metrics