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25 December 2023, Volume 15 Issue 6 Previous Issue    Next Issue

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Prevention and treatment scheme of integrated traditional Chinese and western medicine for respiratory tract infection of Mycoplasma pneumoniae in children in Northeast China WANG Xuefeng, SHANG Yunxiao, CHENG Huanji, WANG Youpeng, FENG Xiaochun, WU Zhenqi, SUN Liping, YANG Nan, QU Shuqiang, WANG Hai, ZHANG Xiuying, CHENG Qi. 2023, 15 (6):  461-466.  Abstract ( 173 )   PDF (846KB) ( 372 )   Save In the autumn and winter of 2023, the number of children with Mycoplasma pneumoniae respiratory tract infections in Northeast China has increased significantly. In order to further standardize the clinical prevention and treatment and give full play to the advantages of integrated traditional Chinese and western medicine treatment, the construction project team of pediatric pneumonia（a key disease） of the National Center for Inheritance and Innovation of Traditional Chinese Medicine, and the pediatric experts of traditional Chinese and western medicine in Northeast China, by referring to the National Health Commission's Guidelines for the Diagnosis and Treatment of Mycoplasma Pneumoniae Pneumonia in Children(2023 Edition) and on the basis of the clinical characteristics of children in the cold regions of Northeast China, have reached a consensus on the classification of Mycoplasma pneumoniae respiratory tract infection, the pathogenesis of traditional Chinese and western medicine, clinical manifestations, imaging and bronchoscopic manifestations, laboratory examination, early warning of important complications, and the treatment of traditional Chinese and western medicine in the infection period, pneumonia period and recovery period. The aim is to effectively solve the clinical problems of Mycoplasma pneumoniae respiratory tract infection and improve the comprehensive abilities of pediatricians in the diagnosis and treatment of Mycoplasma pneumoniae respiratory tract infection, and then promote the development of integrated traditional Chinese and western medicine research in Mycoplasma pneumoniae respiratory tract infection. Related Articles | Metrics

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An empirical study on Professor Ma Rong′s treatment for children′s tic disorder based on data analysis LIU Xuan, ZHANG Xilian, RONG Ping, MA Rong. 2023, 15 (6):  467-473.  Abstract ( 105 )   PDF (1694KB) ( 17 )   Save ObjectiveTo summarize the clinical experience of Professor Ma Rong in differential treatment for children with tic disorder.MethodsThe database of effective cases of tic disorder treated by Chinese medicine was established,and the data were analyzed by frequency distribution,cluster analysis and association rules.ResultsProfessor Ma Rong identified the top 5 TCM syndrome types of tic disorder in children as hyperactivity of liver and wind,external wind,spleen deficiency and phlegm accumulation,spleen deficiency and liver hyperactivity,qi depression turning into fire.The frequency of drugs and the primary and secondary drug combinations of each syndrome type were screened and the core formula was obtained.ConclusionThe core components for live and wind hyperactivity syndrome were Gastrodia,Unguia,cassia,scorpion,chrysanthemum,keel and oyster.The core components for exogenous wind induced syndrome were forsythia,licorice,mint,honeysuckle,Schizonepeta,scutellaria,asparagus,Fructus aurantii,platycodon,burdock seed and scorpion.The core components for spleen deficiency and phlegm accumulation syndrome are calamus,bile south star,Fructus aurantii,pinellia,poria,tangerine peel,licorice,Chuanxiong,gastrodia,scorpion,Chloriti lapis,Lapis chloriti lapis,Radix nochiae and codonopsis.The core ingredients for spleen deficiency and liver hyperactivity syndrome were bupleurum,keel,oyster,licorice,scutellaria,codonopsis,pinellia,magnet,paeony,rigid silkworm,scorpion,cinnamon twig and dried ginger.The core ingredients for Qi depression turning into fire syndrome were bupleurum,ground bone bark,gastrodia,scrophulariae,mulberry bark,peach kernel,pink kudu,calamus,scorpion,psyllium,polygonum,bamboo ru,apogon,Rhizoma japonica,papaya and pinellia. Related Articles | Metrics

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A qualitative study on the compliance of children with tic disorders in the acupuncture treatment CHEN Qian, CUI Xia, WANG Zhongyi, BAI Xue, WANG Handong, LAI Jiawei. 2023, 15 (6):  474-479.  Abstract ( 92 )   PDF (815KB) ( 24 )   Save ObjectiveTo explore the factors that influence the compliance of children with tic disorders in the acupuncture treatment,and then further provide ideas to improve their compliance.MethodsUsing the objective sampling method,semi-structured interviews were conducted with the parents of 15 children who had been diagnosed with tic disorders and had been treated with acupuncture from July 21,2022 to Sep.30,2022.Colaizzi′s method of phenomenological analysis of the interview data was conducted with the help of Nvivo software.ResultsFour main themes were obtained from the interview data:（1）parents′ recognition of acupuncture therapy;（2）parents′ cognition of tic disorders;（3）children′s compliance with acupuncture treatment;（4）cost factor.ConclusionThe awareness and experience of acupuncture therapy and tic disorders in parents of children with tic disorders,the experience and acceptance of children and the treatment cost are the influencing factors of the compliance of children receiving acupuncture treatment for tic disorders.Strengthening the popular science education of acupuncture for tic disorders and improving the correct cognition of parents on tic disorders and acupuncture therapy may help to improve the compliance in acupuncture treatment. Related Articles | Metrics

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Meta analysis of the efficacy and safety of traditional Chinese patent medicine in the treatment of tic disorders in children LI Ruiben, NIE Lianghui, YANG Libin, MA Rong. 2023, 15 (6):  479-485.  Abstract ( 91 )   PDF (3684KB) ( 70 )   Save ObjectiveTo systematically evaluate the efficacy and safety of traditional Chinese patent medicine in the treatment of tic disorders in children.MethodsRandomized controlled trials of traditional Chinese patent medicine in the treatment of tic disorders in children were comprehensively searched in CNKI,Wanfang Database,VIP,China Biomedical Database,Pubmed,Embase and Cochrane Library.Two independent researchers screened and evaluated the quality of the literature based on pre-set inclusion and exclusion criteria,and made a meta-analysis of the included literature using RevMan 5.3 software.ResultsA total of 3 088 pediatric patients were ultimately included in 12 studies.Meta analysis showed that the effective rate of traditional Chinese patent medicine was higher than that of the placebo group,with a statistically significant difference ［RR=2.06 (1.63，2.62),P<0.000 01］.The effective rate of traditional Chinese patent medicine was not significantly different from that of tiapride hydrochloride ［RR=1.03 (0.98，1.07),P=0.23］.In terms of tic severity,traditional Chinese patent medicine could significantly reduce the total score of YGTSS compared with placebo ［MD=-7.84 (-10.18,-5.51),P<0.000 01］.Comparing traditional Chinese patent medicine with tiapride hydrochloride,there was no statistically significant difference in the reduction of the total score of YGTSS ［MD=-0.32 (-1.21,0.58),P=0.75］.In terms of adverse events,the incidence of dizziness,fatigue and sleepiness of traditional Chinese patent medicine was lower than that of tiapride hydrochloride.ConclusionTraditional Chinese patent medicine is effective and safe in the treatment of tic disorders in children,which still needs to be confirmed by more high-quality randomized controlled studies. Related Articles | Metrics

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Clinical observation of Qufeng Zhidong prescription in the treatment of exogenous wind syndrome of tic disorder in children WANG Minhua, GUO Xinxue, XIONG Zenan, ZHANG Ziqi. 2023, 15 (6):  486-489.  Abstract ( 77 )   PDF (815KB) ( 95 )   Save ObjectiveTo investigate the clinical efficacy of Qufeng Zhidong prescription in the treatment of children with exogenous wind syndrome of tic disorder. MethodsFrom February 2021 to June 2022 in the pediatric clinic of Yixing Hospital of Traditional Chinese Medicine,80 children diagnosed with exogenous wind syndrome of tic disorder were randomly divided into treatment group and control group,40 cases in each group.The treatment group was treated with Qufeng Zhidong prescription taken orally,while the control group was treated with tiapride hydrochloride taken orally.Both groups were treated for 8 weeks.The total clinical effective rate,changes in TCM syndrome score before and after treatment,changes in tic symptom severity scale score before and after treatment,recurrence rate and adverse reactions were compared between the two groups.ResultsThe total effective rate was 92.5%（37/40） in the treatment group and 75.0%（30/40） in the control group.There was significant difference between the two groups (P<0.05).After 60 days of treatment,the scores of tic severity and TCM clinical syndromes in both groups were lower than those before treatment,and the scores in the treatment group were significantly lower than those in the control group(P<0.05).At the 3-month and 6-month follow-up,there was no statistical difference in the recurrence rate between the two groups(P>0.05).ConclusionQufeng Zhidong prescription has a good clinical effect in the treatment of children exogenous wind syndrome of tic disorder,which can significantly improve the clinical signs and symptoms of children and has high safety,and is worthy of further study. Related Articles | Metrics

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Study on the prescription and syndrome of vocal tics YANG Yue'e, HAN Xinmin. 2023, 15 (6):  490-493.  Abstract ( 113 )   PDF (786KB) ( 317 )   Save Based on the syndrome-differentiation method of prescriptions corresponding with syndromes and long-term experience in clinical practice, the vocal tics in children is classified as the following four syndromes of traditional Chinese medicine (TCM): Sangen decoction syndrome (with the characteristics of mild congestion of throat, enlarged tonsils and follicular hyperplasia on the posterior wall of throat, which is common after respiratory tract infection), Banxia Houpu decoction syndrome (characterized by sense of foreign body in throat and sputum attached to posterior wall of throat on examination), Xifeng Ditan decoction syndrome (with the characteristics of involuntary shouting or filthy speech, no abnormalities on throat examination), and Liuwei Dihuang decoction syndrome (characterized by dry throat and clearing throat, red tongue and little coating, thread and rapid pulse, and dark redness of posterior wall of throat on examination). The prescriptions are made correspondingly, which include empirical formulas and famous ancient formulas, and three cases are enclosed. Related Articles | Metrics

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Progress in the clinical features and treatment of pediatric heart failure ZHAO Qi, SUN Shuna. 2023, 15 (6):  494-499.  Abstract ( 155 )   PDF (861KB) ( 185 )   Save Heart failure is a clinical syndrome caused by structural or functional abnormalities of the heart，which result in limited cardiac contraction and/or filling，and cardiac output cannot meet the body′s demand.Heart failure is one of the common critical diseases in children.Since all organs of children are not yet mature，if heart failure cannot be corrected，all organs are more likely to be damaged,leading to complications and sequelae，which not only seriously jeopardize children′s lives and health，but also bring heavy medical burden to families and society due to difficulty in treatment and poor prognosis.The etiology，pathophysiological characteristics，and treatments of heart failure in children are very different from those of adult heart failure.The main cause of heart failure in children is congenital cardiovascular abnormalities，while other causes include myocarditis，cardiomyopathy，and coronary artery abnormalities.Adrenergic receptor expression levels，miRNA profiles，and expression of genes associated with myocardial abnormalities differ between children and adults.The treatment for heart failure in children includes etiologic treatment，pharmacotherapy，cell-based therapy，and auxiliary device therapies.Treatment and long-term management regimens for heart failure in children are more challenging than those in adults.This article will review the epidemiology，etiology，pathophysiological features，and treatment of heart failure in children. Related Articles | Metrics

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Professor Wang Xuefeng′s treatment for children with asthma of pneumonia from lungs and intestines based on the theory of "To treat diseases of Zang through managing Fu" CAI Zhuang, WANG Xuefeng, YANG Jianshu. 2023, 15 (6):  500-503.  Abstract ( 116 )   PDF (791KB) ( 6 )   Save Children are not fully developed in physical shape and qi,and their defence function is weak.When the exogenous evil invades,the lungs are the first to be attacked. Lungs are very likely to be affected by cold or heat,so they are easily damaged and the damage may linger and it is difficult to be managed.Comprehensive Theory on Deficiency and Excess of Essential Questions states that "The diseases of five Zang result from the blocking of six Fu".This article combs Prof.Wang Xuefeng′s experience in treating asthma of pneumonia based on the theory of "To treat diseases of Zang through managing Fu". First,the origin of the theory of "To treat diseases of Zang through managing Fu"（the Theory） is elaborated form the association between physiology and pathology of Zang and those of Fu.Then,based on the pathophysiological features of children,the pathogenic key to the Theory in the development of asthma of pneumonia is that the heat in lungs spreads to the large intestine.Finally,the treatment principles are summarized by further explaining the feasibility of the Theory based on modern researches.The basic principle in the treatment is "Taking away the firewood from under the cauldron",meaning to treat the diseases by managing the root causes,that is,to clear lungs and phlegm and to stop cough and asthma.According to the stool of children,the children′s bowel movement is kept smooth by unblocking Fu in order to expel the evil.By way of treating the diseases of Zang through managing Fu,the Zang and Fu are in good state,the disease course is shortened,and the therapeutic effect is improved,in which way the diseases are prevented form becoming critical.Here a case is provided for verification. Related Articles | Metrics

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Influence of "Fuyang Tongjing" Dumai moxibustion on balance function of children with spastic cerebral palsy MA Yanli, BAN Huihui, WU Li, REN Maiqing. 2023, 15 (6):  504-509.  Abstract ( 78 )   PDF (831KB) ( 8 )   Save ObjectiveTo observe the effect of "Fuyang Tongjing" Dumai moxibustion on balance function of children with spastic cerebral palsy. MethodsBy the random number table,78 children with spastic cerebral palsy were randomly divided into control group(n=39) and treatment group (n=39).The both groups were given multimedia sensory integration training,suspension training and goal-directed training;additionally,the treatment group was given "Fuyang Tongjing" Dumai(Shenting,Dazhui,Zhiyang,Shenzhu,Jinsuo,Mingmen) moxibustion;the treatment lasted for 6 months.The scores of the Early Clinical Assessment of Balance scale,the Gross motor function measurement 88 scale and the ADL Rehabilitation Nursing Rating Scale for children with spastic cerebral palsy were compared between the control group and treatment group,and their correlations were compared. ResultsAfter treatment,there was statistical difference in the improvement of balance function in the children with cerebral palsy. "Fuyang Tongjing" Dumai moxibustion combined with conventional rehabilitation training was better than conventional rehabilitation training alone(P<0.05).After treatment,the total scores of GMFM88 and the scores of ADL Rehabilitation Nursing Rating Scale in children with cerebral palsy significantly increased in both groups,and the scores of the treatment group were higher than those of control group(P<0.05).The comparison in the energy areas of GMFM88 between the two groups showed:the scores in the four areas(supine position and turning over,sitting position,crawling and kneeling position,standing position) significantly increased after treatment compared with those before treatment(P<0.05);the scores in the energy areas of walking,running and jumping significantly increased in the treatment group after treatment(P<0.01).After treatment,the scores in the two energy areas of crawling and kneeling position and standing position were higher in the treatment group than in the control group(P<0.05).Before treatment,the ECAB score was positively related to GMFM88 total score and the scores of ADL Rehabilitation Nursing Scale(r=0.860,0.704,0.760,0.688,P<0.01) in both groups;after treatment,ECAB score was positively associated with GMFM88 total score and the scores of ADL Rehabilitation Nursing Scale in both groups(r=0.884,0.745,0.794,0.651,P<0.01).Conclusion"Fuyang Tongjing" Dumai moxibustion can improve the balance function of children with spastic cerebral palsy,and the improvement in balance function is helpful to promote the development of motor function and ability of daily activities. Related Articles | Metrics

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Clinical study on the treatment for childhood tic disorder with spleen deficiency and phlegm aggregation based on the theory of "brain-gut axis" by Kongsheng Zhenzhong pills and Erchen decoction with spleen deficiency and phlegm aggregation HUANG Liwei, JIANG Kai 2023, 15 (6):  510-513.  Abstract ( 140 )   PDF (794KB) ( 25 )   Save Tic disorders(TD) in children are chronic neuropsychiatric disorders that are complicated with inattention,hyperactivity,learning difficulties,obsessive-compulsive movements,and other behavioral disorders,which have a significant impact on the physical and mental health of the children and are worthy of attention. In recent years,the research on the "brain-gut axis" has become a popular topic,and the relationship between the "brain-gut axis" and neurological and psychiatric disorders has become a problem that people want to solve,which also has important implications for the disease course and progression of tic disorders. In this paper,based on the theory of "brain-gut axis",we analyze the connection between brain-gut axis and tic disorders,and discuss the clinical study of Kongsheng Zhenzhong pills and Erchen decoction in the treatment of tic disorders in children with spleen deficiency and phlegm aggregation,in order to provide new differentiated ideas for TCM treatment of pediatric tic disorders. Related Articles | Metrics

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Clinical observation on antipyretic effect of external external application of TCM granules on babies aged 0-4 months infected with COVID-19 WANG Guiling, YANG Jiang, WANG Yuanyuan, GENG Yuzuo. 2023, 15 (6):  514-517.  Abstract ( 71 )   PDF (820KB) ( 122 )   Save ObjectiveTo observe the antipyretic effect of external application of self-made TCM granules on babies aged 0-4 months infected with COVID-19.MethodsTotally 132 babies aged 0-4 months with moderate fevel or above due to COVID-19 infection were chosen,who were treated in Suqian TCM Hospital from Nov. 2022 to Jan. 2023,and they were divided into two group:68 in observation group and 64 in control group.In control group,the babies with body temperature ≥38 ℃ were given medical antipyretic patches on their forehead;in observation group,the babies received external application of self-made TCM granules on Shenque acupoint;after 3 days of treatment,the antipyretic effect was recorded.For those with bacterial infection,febrile convulsions,etc.,the symptomatic treatment of anti-infection,fluid supplimentation and stopping convulsions was performed.Compare the antipyretic effect and the starting time of antipyretic effect after treatment between the two groups.ResultsThe total effect rate of observation group was 92.65%(63/68),significantly higher than that of control group(76.56%,49/64),and the differences were statistically significant(P<0.05).The dorp in temperature of observation group at 6h,24h,48h and 72h after treatment was greater than that of control group(P<0.05).The starting time of antipyretic effect in observation group was prior to that in control group,and there was statistical difference between the two groups(P<0.05).ConclusionThe external application of self-made TCM granules has significant antipyretic effect on the babies aged 0-4 month infected with COVID-19;it can greatly shorten the duration of moderate fever or above and fasten the starting of antipyretic effect,and there is no adverse reaction,so it is worthy of clinical application. Related Articles | Metrics

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To explore the medication rules of Professor Guan Lijun′s treatment for children′s sleep disorders based on the TCM inheritance assistance platform QU Di, HAO Yawen, GUAN Lijun, WANG Shuang, XU Yihan, GAO Shan. 2023, 15 (6):  518-523.  Abstract ( 84 )   PDF (863KB) ( 7 )   Save ObjectiveTo study and summarize the characteristics and rules of Professor Guan Lijun′s medication in the treatment of children′s sleep disorders by using data mining technology and statistical analysis.MethodsThrough retrospective study,120 TCM prescriptions for sleep disorders treated by Professor Guan Lijun in Shenyang Children′s Hospital from January 2021 to June 2023 were collected and analyzed statistically by TCM inheritance platform (V2.5) software.ResultsA total of 22 traditional Chinese medicines were used more than 20 times.Their properties were mainly warm,cold and calm,and their tastes were mainly sweet,bitter and spicy,mainly functioning through the spleen,heart,liver,stomach and kidney channels.By association rule analysis 25 pairs of drug compatibility combinations and 11 association rules were obtained;by cluster analysis combined with clinical experience 4 groups of cluster drug combinations were obtained,which could be used for new prescriptions.ConclusionProfessor Guan Lijun′s treatment for sleep disorders is based on nourishing kidney water,replenishing liver blood,clearing heat,calming heart and calming the mind,centering on regulating spleen and stomach,and practicing the therapeutic principles of calming the heart,soothing the liver and tonifying the kidney.The therapeutic methods of calming the heart and calming the mind,calming the liver and suppressing Yang,clearing heat and expelling fire,and soothing the liver and regulating Qi are used,which provides new insights for guiding clinical medication. Related Articles | Metrics

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Clinical observation on acute cough of recurrent respiratory tract infections in children treated by Xingsu powder with modification XIONG Jiaxiu, ZHAO Xiaomin. 2023, 15 (6):  523-526.  Abstract ( 155 )   PDF (786KB) ( 98 )   Save ObjectiveTo observe the clinical efficacy of Xingsu powder with modification in the treatment of acute cough of recurrent respiratory tract infections(RRTIs) with external evil inducing phlegm and fluid retention.MethodsFracute cough of RRTIs with external evil inducing phlegm and fluid retention were treated in the pediatric outpatient department of the Second Affiliated Hospital of Jiangxi University of TCM,and they were selected and randomly divided into a control group and an observation group,with 54 cases in each group.The control group was given symptomatic treatment with ambroxol oral solution and inhalation of budesonide solution,and on this basis,the observation group was given Xingsu powder with modification.After 6 days of the above treatment,the clinical efficacy,clinical symptom score,adverse reaction and secondary chronic cough of the two groups were compared.ResultsAfter treatment,the total clinical efficiency rate of observation group was 96.30%(52/54),higher than that of control group(83.33%,45/54),and the clinical symptom score was significantly reduced compared with that of control group,the difference bring statistically significant(P<0.05);during the treatment,there was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05);the 4-week follow-up showed that the rate of secondary chronic cough in observation group was 11.11%(6/54),lower than that in control group(25.93%,14/54)(P<0.05).ConclusionXingsu powder with modification can improve the clinical effect,improve symptoms and reduce the rate of secondary chronic cough in children with acute cough of recurrent respiratory tract infections,which is worthy of clinical promotion.om November 2019 to November 2022,108 cases of  Related Articles | Metrics

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Study on the medication rules of insect medicine compound in the treatment of children with tic disorder ZHANG Yutong, XIE Bin. 2023, 15 (6):  527-531.  Abstract ( 64 )   PDF (802KB) ( 11 )   Save ObjectiveTo explore the medication rules or insect medicine compound in the treatment of children with tic disorder (TD).MethodsBy comprehensively collecting and sorting out the insect compound prescriptions of traditional Chinese medicine in the treatment of children's TD in CNKI and Wanfang databases, and using the Traditional Chinese Medicine Inheritance Support Platform, the medication rules of insect medicine compound in the treatment of children's TD were mined and analyzed.ResultsIn this study, 134 insect compound prescriptions were screened, involving 173 traditional Chinese medicines. Among them, there were 17 kinds of insect drugs, with a total of 357 times of application. Bombyx batryticatus, scorpion, cicada slough and keel were used more frequently in insect drugs. In the compound, the compatibility frequency of five kinds of drugs was the highest, involving the drugs calming liver and stopping wind, tonifying deficiency, relieving exterior symptoms, clearing heat, resolving phlegm and relieving cough and asthma, accounting for 69.86%(1 217/1 742) of the total application. The drug properties of the compound Chinese medicine were cold, neutral and warm, accounting for 90.47% (1 576/1 742). The drugs of sweet, pungent and bitter flavor accounted for 82.55%(2 072/2 510). The drugs functioning through liver, spleen and lung meridians accounted for 53.96%(2 214/4 103). ConclusionThe application of insect medicine compound in the treatment of TD in children can give full play to the advantages of insect medicines, such as dredging collaterals and searching wind, eliminating phlegm and calming liver and stopping wind and movement, in order to calm liver and stop wind, remove phlegm and fire, tonify spleen and kidney, and promote blood circulation and remove blood stasis, while paying attention to regulating qi movement of the whole body. All of these are the characteristics of traditional Chinese medicine in the clinical treatment of TD in children. Related Articles | Metrics

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Analysis of the clinical characteristics of leukemoid reaction in children SONG Yulei, LUO Haiyan, FAN Jianghua, YANG Longgui, XIAO Zhenghui. 2023, 15 (6):  531-535.  Abstract ( 76 )   PDF (815KB) ( 126 )   Save ObjectiveTo explore the clinical features of leukemoid reaction (LR) in children and the key points of differentiation from leukemia.MethodsThe clinical data of 89 children with leukocyte ≥30×109/L admitted to the internal medicine ward of Hunan Children's Hospital in the past two years (LR group) were retrospectively analyzed,including 44 cases of leukemoid reaction and 45 cases of leukemia.Another 89 children with non-leukemoid reaction(leukocyte <30×109/L) admitted in the same period were selected as the control group(NLR group).The general data,laboratory examination,hospital stay,discharge diagnosis and other clinical data of LR group and control group were statistically analyzed.The difference in laboratory indexes between LR group and leukemia group was compared.ResultsCompared with the non-leukemoid reaction(NLR) group,the ≥30×109/L group had a higher proportion of fever patients,longer hospital stay,higher neutrophil ratio and higher positive rate of blood culture.Pneumonia was the main diagnosis in the LR group,and the incidence of lung consolidation was statistically different between the two groups(P<0.05).The LR group in bacteremia patients had a higher gram-positive infection rate.The proportion of patients with leukocyte count ≥50×109/L in leukemia group was significantly higher than that in LR group,and there were statistically significant differences in platelet count,C-reactive protein,uric acid and lactate dehydrogenase levels between leukemia group and LR group.ConclusionChildren with LR usually have a clear etiology and are at high risk for pneumonia and lung consolidation.A combination of clinical features and laboratory indicators can help early identification of leukemia in patients with leukocytosis. Related Articles | Metrics

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Diagnostic value of complement level in premature infants with early-onset sepsis ZHAO Gai. 2023, 15 (6):  536-539.  Abstract ( 71 )   PDF (825KB) ( 19 )   Save ObjectiveTo study the role of complement C3 and C4 in the early identification of premature infants with early-onset sepsis, and to analyze their predictive value for sepsis complicated with different sites of infection.MethodsThe clinical data of 72 preterm infants with sepsis (sepsis group) and 18 normal preterm infants (control group) were retrospectively analyzed, who were treated in the First Affiliated Hospital of Zhengzhou University from Jan. 2022 to Dec. 2022. The difference in complement levels between the two groups was analyzed. The sepsis group was divided into three subgroups: sepsis with suppurative meningitis group, sepsis with shock group and simple sepsis group. The differences in complement levels between the three subgroups and the normal control group were compared. ROC curve was used to analyze the predictive value of complement levels for infection in the three subgroups.ResultsThere was no significant difference in complement levels between the sepsis group and the normal control group(P>0.05). The level of complement C3 and C4 in sepsis with suppurative meningitis group was higher than that in control group, and the difference was statistically significant (P<0.05). The levels of complement C3 in the sepsis with shock group and the simple sepsis group were lower than those in the control group, and the differences between the two groups were statistically significant(P<0.05). The levels of complement C4 in the sepsis with shock group and the simple sepsis group were lower than those in the control group, but the difference was not statistically significant(P>0.05). The predictive value of complement level for sepsis combined with shock and sepsis alone was high, but the predictive value for sepsis combined with suppurative meningitis was not high.ConclusionComplement levels are significantly different in children with sepsis complicated with different sites of infection or at different stages of the same infection. Dynamic detection of complement levels may be helpful for the early diagnosis and differential diagnosis of sepsis and its corresponding complications in preterm infants. Related Articles | Metrics

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Effect of different doses of recombinant human interferon α 2b on serum SIRT1 levels in children with bronchiolitis QIN Yuanyuan, ZHANG Wenjie, WANG Qingqing. 2023, 15 (6):  540-544.  Abstract ( 57 )   PDF (812KB) ( 9 )   Save ObjectiveTo investigate the effects of different doses of recombinant human interferon α2b (rhIFNα2b) on serum silent information regulator 1 (SIRT1) levels in children with capillary bronchitis.MethodsTotally 102 children with bronchiolitis admitted to our hospital from April 2021 to April 2022 were randomly divided into a control group and an observation group,with 51 cases in each group.Both groups received routine basic treatment;additionally,the control group received nebulized inhalation of rhIFN α2b injection at 100 000 IU/(kg·dose),while the observation group received nebulized inhalation of rhIFN α2b injection at 200 000 IU/(kg·dose),both being treated for 5 days.Compare the differences in clinical symptom scores,disappearance time of symptoms and signs,lung function indicators,blood gas indicators,SIRT1 and cellular immune indicators between the two groups before and 5 days after treatment,and evaluate the safety of treatment.ResultsAfter 5 days of treatment,the clinical symptom scores of cough,wheezing,wheezing rale,and triple concave syndrome in the observation group were lower than those in the control group (P<0.05).The disappearance time of various clinical indicators and hospitalization time in the observation group were shorter than those in the control group(P<0.05).After 5 days of treatment,PTEF,VT,TPTEF/TE,SaO2,PaO2,and SIRT1 in the observation group were higher than those in the control group,and their Rrs,PaCO2,EOC,and ECP were lower than those in the control group(P<0.05).ConclusionThe rhIFNα2b is effective and safe in the treatment of pediatric capillary bronchitis,and compared with 100 000 IU/(kg·dose),200 000 IU/(kg·dose) is more effective in relieving clinical symptoms and signs,improving lung function and blood gas,regulating body immunity and SIRT1 levels. Related Articles | Metrics

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Clinical application of behavior training based on cross-theoretical model in the rehabilitation of children with epilepsy ZHU Hui, CHENG Jusen, ZHANG Man. 2023, 15 (6):  544-548.  Abstract ( 71 )   PDF (839KB) ( 12 )   Save ObjectiveTo explore the clinical application of behavior training based on trans-theoretical model (TTM) in the rehabilitation of children with epilepsy through single-blind design.MethodsA total of 95 children with epilepsy admitted to the pediatric Department of the First Affiliated Hospital of Xinxiang Medical College from January 2021 to December 2022 were randomly divided into observation group (48 cases) and control group (47 cases). The control group was given routine health behavior training including medication management, healthy lifestyle and interpersonal communication. The observation group received behavioral training intervention based on TTM in addition to the treatment for control group; compare the total effective rate of rehabilitation, emotional state (children's anxiety mood disorder scale score and children's depression disorder self-rating scale score), self-esteem level (self-esteem scale score), adaptive behavior (independent functional factors, cognitive functional factors and social/self-control factors) of the two groups.ResultsThe total effective rate of rehabilitation in the observation group was 91.67% (44/48), higher than that in the control group (76.60%, 36/47), and the difference was statistically significant (P<0.05). After intervention, the scores of the anxiety mood disorder scale and the self-rating scale of depressive disorder in children in the two groups were significantly lower than those before intervention, and the observation group was lower than the control group; the score of self-esteem scale was significantly higher than that before intervention, and the observation group was higher than the control group, and the difference was statistically significant (P<0.05). The adaptive behavior scores of the two groups after intervention were significantly higher than those before intervention, and the observation group was higher than the control group (P<0.05).ConclusionBehavioral training based on TTM is effective in the rehabilitation of children with epilepsy, which can effectively improve their emotional state, self-esteem level and social adaptive behavior. Related Articles | Metrics

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Impact of ABA training combined with 60-point mother theory on rehabilitation treatment for children with autism  YANG Yafei, SHANG Qing, LYU Nan, YIN Wenhan, WU Mingxia. 2023, 15 (6):  549-552.  Abstract ( 80 )   PDF (787KB) ( 596 )   Save ObjectiveTo explore the impact of applying behavioral training (ABA) combined with the "60-point mother theory" on the rehabilitation treatment of children with autism.MethodsTotally 62 children with autism admitted to the Rehabilitation Center from June 2020 to January 2022 were selected as the research subjects. According to the principle of matching basic features between groups, they were divided into a control group and an observation group, with 31 cases in each group. The control group received comprehensive rehabilitation treatment, with ABA training as the main intervention. The observation group received ABA training combined with the "60-point mother theory" as an auxiliary guide. The autism behavior of the two groups of children before treatment and three months after treatment were compared by Autism Behavior Checklist(ABC). The Psychological Education Scale (PEP-3) for autism spectrum and related developmental disorders was used to make a comprehensive evaluation of the children with autism.ResultsAfter 3 months of intervention, the improvement in PEP-3 scores in the observation group was significantly better than that in the control group(P<0.05).The total ABC scores of the two groups were lower on discharge than on admission, and the observation group was lower than the control group(P<0.05).ConclusionThe use of ABA training combined with the "60-point mother theory" is of great significance in children with autism, as it can effectively improve the overall developmental functional level and alleviate clinical symptoms of children with autism. Related Articles | Metrics