Table of Content

25 February 2024, Volume 16 Issue 1 Previous Issue    Next Issue

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Expert consensus on external treatment for tic disorder in children with traditional Chinese medicine(2024) Wang Xuefeng, Han Xinmin, Sun Kexing, Jiang Yonghong, Rong Ping 2024, 16 (1):  1-7.  Abstract ( 369 )   PDF (1087KB) ( 312 )   Save Tic disorder is one of the most common neuropsychiatric diseases in children in clinical practice, which does great harm to children's physical and mental health. External therapy with traditional Chinese medicine, represented by acupuncture and massage, has some special advantages in the treatment of tic disorder in children, but it needs to be further standardized. This consensus covers the terms and definitions of tic disorder in children, the diagnosis, etiology and pathogenesis, syndrome differentiation and technological standards of external therapy with traditional Chinese medicine, and summarizes the modern medical experience and the advances in evidence-based medicine of this disease. This consensus highlights the clinical practicality and reflects the latest research progress, which helps to improve the level of clinical standardization of external therapy for tic disorder in children with traditional Chinese medicine. Related Articles | Metrics

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Exploring the differentiation and treatment strategies for functional constipation in children based on Wan Quan′s theory of "No Use of Attacking Method in Spite of the Condition ZHANG Yifei, DONG Yingmei, ZHAO Xia, PAN Qingyun, YAN Hua.Nanjing 2024, 16 (1):  7-11.  Abstract ( 144 )   PDF (1059KB) ( 372 )   Save Functional constipation (FC) is a common gastrointestinal disease in children.The global prevalence of functional constipation in children is about 0.5% to 32.2%,which seriously affects the quality of life of children.Wan Quan is a famous pediatric doctor in ancient China,who innovatively put forward the idea of "spleen insufficiency" in children,and paid attention to regulating the spleen and stomach,which has an important guiding role in the diagnosis and treatment of modern pediatric diseases.Wan Quan put forward the general principle of the treatment for pediatric constipation in "Infant Family Secrets:Volume Ⅳ:Urination and Defecation Diseases":"The stool induration should be attacked,but sometimes is attacking method useless in spite of the condition".Based on Wan Quan′s theory of "spleen insufficiency",and "The stool induration should be attacked,but sometimes attacking method is useless in spite of the condition",and combined with modern research progress,it is proposed that the causes of FC in children are mostly attributed to dryness-heat accumulation,stagnation of milk and food,spleen deficiency leading to transportation failure,qi stagnation,and blood deficiency resulting in intestinal dryness.Spleen deficiency leading to food injury is considered to be the key pathogenesis;therefore,it is recommended that the treatment for FC in children should differentiate deficiency from excess,and carry out the principle of activating spleen to assist the transportation throughout the treatment process.This study explores the differentiation and treatment strategies for FC in children from the aspects of acute purgation,digestion and elimination of accumulated stagnation,slow purgation,regulating qi,and moistening dryness,etc.,in order to provide a reference for the clinical diagnosis,treatment,and care of FC in children. Related Articles | Metrics

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Exploring the differentiated treatment for functional constipation in children based on the "Harmony Method" YUAN Zhenhua, WANG Junhong, ZHANG Qiang, LIU Miaomiao 2024, 16 (1):  12-15.  Abstract ( 138 )   PDF (1032KB) ( 184 )   Save Functional constipation in children is one of the common diseases in pediatrics,and this study aims to explore the treatment for this disease in traditional Chinese medicine(TCM),with the "Harmony Method" as the core theoretical framework.Firstly,the historical origin and theoretical connotation of the "Harmony Method" are traced,and its core concepts and application background are elaborated in depth.Secondly,it is believed that "loss of harmony of qi and misdirection of conduction" is the core mechanism of the disease,emphasizing the interconnection between qi and the large intestine.The principles of treating this disease are further discussed in depth,and it is proposed that "eliminating evils and supporting vital qi,harmonizing the qi and regulating the qi,and communicating  Related Articles | Metrics

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Professor Wang Xuefeng′s experience in the treatment of functional constipation in children based on the theory of "brain-gut relatedness GUO Tianxiang, ZHANG Xiuying, WANG Xuefeng, WANG Shuyu. 2024, 16 (1):  15-18.  Abstract ( 142 )   PDF (1038KB) ( 22 )   Save Functional constipation in children is a common disease in pediatrics,which is mainly manifested as difficulty in defecation,reduced frequency of defecation and/or prolonged defecation.The incidence and recurrence rate of this disease is relatively high,and at the same time,functional constipation seriously affects the quality of life of children,which is unfavorable to the growth and development of children.In recent years,with the increase of social pressure,the incidence of this disease has been increasing year by year;in addition to physical symptoms,children′s mental symptoms also gradually gain concern,and very often functional constipation is accompanied by abnormal emotional symptoms in children.The mechanism of functional constipation is mainly "abnormal interaction between the brain and intestines" as proposed in Rome Ⅳ,which is also related to the holistic concept of "five organs as one" and the theoretical view of form and spirit being all as one in Chinese medicine,so this article takes the theory of "brain-intestine correlation" and the "brain-intestine axis" in modern medicine as the entry point to make an in-depth analysis of the doctrine of "brain-intestine correlation".Based on the special connection between the brain and the intestine,which are physiologically related to each other and pathologically influenced by each other,we believe that the treatment for functional constipation should not only regulate the gastrointestinal function to improve intestinal symptoms,but also pay attention to the role of the heart and brain in regulating the spirit to improve the patient′s anxiety,depression and other mental symptoms,and explore the treatment method of regulating the spirit to achieve the effect of intestinal transport,aiming to find a new way of thinking about the treatment for functional constipation,and provide a new method to improve the quality of life of children with functional constipation. Related Articles | Metrics

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Research progress in the treatment of idiopathic precocious puberty in girls with Chinese medicine ZHOU Fangyuan, ZHAO Jun, SONG Qinli, YANG Chuwen, LU Xiaoye, LI Jiaqi. 2024, 16 (1):  19-22.  Abstract ( 141 )   PDF (1035KB) ( 321 )   Save In recent years， with the continuous improvement of living standards， the incidence rate of precocious puberty in children has increased year by year. In traditional Chinese medicine it is believed that precocious puberty is closely related to liver， spleen， and kidney dysfunction， with a complex pathogenesis. Traditional Chinese medicine has a significant therapeutic effect on precocious puberty. This article reviews the differentiated treatment experience， clinical research， and experimental research in the treatment of idiopathic precocious puberty in girls with traditional Chinese medicine in the past 5 years， in order to provide reference for further development in this field. Related Articles | Metrics

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Research progress of vitamin D deficiency in children WANG Chunyan, TANG Yongzai, QIAO Pei, WANG Lanying. 2024, 16 (1):  22-25.  Abstract ( 119 )   PDF (1061KB) ( 98 )   Save In recent years, with the development of medical and health care, vitamin D deficiency (VDD) has received more and more attention in the growth and development of children, and the incidence is high. Vitamin D is mainly derived from vitamin D3 transformed by skin exposure to sunlight. VDD is mainly manifested as rickets and tetany. At present, the diagnostic criteria for VDD are still controversial, and the treatment plan is generally divided into daily and weekly treatment plans. This article reviews the research progress on VDD in children from epidemiology, metabolic mechanism and etiology, clinical manifestations, diagnosis, treatment and prevention, in order to provide some clinical reference for VDD in children.  Related Articles | Metrics

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Effects of Dingchuan granules on viral load and airway resistance in lung tissue of young rats with respiratory syncytial virus pneumonia ZHOU Tao, ZHANG Xiuying, WANG Xuefeng, WANG Yongxue, ZHAO Hangyu, WEI Chenhao. 2024, 16 (1):  26-30.  Abstract ( 78 )   PDF (1084KB) ( 19 )   Save ObjectiveTo investigate the effects of Dingchuan granules on viral load, inflammatory factors and airway resistance in lung tissue of young rats with respiratory syncytial virus(RSV) pneumonia.MethodsThirty young SD mice were randomly divided into three groups: normal group, RSV pneumonia group, and Dingchuan granules intervention group, with 10 mice in each group. Establish RSV pneumonia model using nasal drip method. Double chamber tracing method was used to detect airway resistance in mice, and hematoxylin eosin staining (HE staining) method was used to observe pathological changes in lung tissue. ELISA method was used for detecting the content of interleukin-8 (IL-8) and tumor necrosis factor (TNF-α) and interleukin-1β (IL-1β) in alveolar lavage fluid(BALF). Results（1）Viral load: Compared with the normal group, RSV pneumonia group and Dingchuan granules intervention group had higher viral load (P<0.05).Compared with the RSV pneumonia group, the viral load in the Dingchuan granules intervention group was significantly lower (P<0.05). （2） In terms of airway resistance: Compared with the normal group, both the RSV pneumonia group and the Dingchuan granules intervention group showed an increase in airway resistance (P<0.05). Compared with the RSV pneumonia group, the airway resistance of the Dingchuan granules intervention group was significantly reduced (P<0.05). （3） In terms of pathological injury and dry-to-wet ratio: Compared with the normal group, the RSV pneumonia group and the Dingchuan granules intervention group showed an increase in pathological injury score and lung wet-to-dry ratio (P<0.05). Compared with the RSV pneumonia group, the pathological injury score and lung wet-dry ratio of the Dingchuan granules intervention group were both reduced (P<0.05). （4）In terms of IL-8 ,TNF-α and IL-1β content in BALF: Compared with the normal group, the RSV pneumonia group and the Dingchuan granules intervention group had significant increase in IL-8，TNF-α and IL-1β content (P<0.05). Compared with the RSV pneumonia group, the Dingchuan granules intervention group showed significant decrease in the content of IL-8, TNF-α and IL-1β(P<0.05). ConclusionDingchuan granules can reduce the viral load in lung tissue, reduce airway resistance, improve the degree of lung injury, and inhibit the level of inflammatory factors of RSV pneumonia in young rats. Related Articles | Metrics

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Meta-analysis of the efficacy of Maxing Shigan decoction combined with western medicine in the treatment of community-acquired pneumonia in children WU Pan, WANG Xuefeng, HUANG Tingyue, ZHANG Tao. 2024, 16 (1):  31-37.  Abstract ( 108 )   PDF (4090KB) ( 110 )   Save ObjectiveTo systematically evaluate the efficacy and safety of Maxing Shigan decoction combined withconventional western medicine in the treatment of pneumonia in children.MethodsRandomized controlled trials of combined use of Maxing Shigan decoction in the treatment of childhood pneumonia were searched by computer in the databases at home and abroad, which were published from the establishment of databases to August 1, 2023. Two researchers conducted literature screening and data extraction separately, and the quality of the included studies was evaluated. Meta-analysis was performed using RevMan 5.3 software.ResultsA total of 9 studies were included, involving a total of 1 005 patients, including 504 patients in the experimental group and 501 patients in the control group. The results of Meta-analysis showed that the total effective rate of combined use of Maxing Shigan decoction in the treatment of children with pneumonia［RR＝1.16，95%CI（1.11,1.22）,P<0.000 01］, the time of cough disappearance［SMD=-1.60,95%CI (-1.81,-1.39),P<0.000 01］, fever relief time［SMD=-1.43,95%CI (-2.04,-0.82),P<0.000 01］, lung rale disappearance time［SMD＝-1.35,95%CI（-1.55,-1.15）,P<0.000 01］, and the levels of serum CRP after treatment in the experimental group were better than those of control group, and the incidence of adverse reactions and complications was better than that of control group［RR=0.41,95%CI(0.18,0.95)，P=0.04］.ConclusionMaxing Shigan decoction combined with conventional western medicine is effective, and is also safer than conventional western medicine in the treatment of children with pneumonia, but high-quality RCT studies are needed for further verification.  Related Articles | Metrics

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A case report and literature review of Alstrom syndrome MA Mingxing, ZHANG Junguang, ZHOU Suxiang. 2024, 16 (1):  38-41.  Abstract ( 75 )   PDF (1055KB) ( 108 )   Save ObjectiveTo report the diagnosis and treatment process of a patient with Alstrom syndrome to improve clinical understanding of this disease.MethodsAnalyze the clinical manifestations, laboratory tests, diagnosis, and treatment process of a patient with Alstrom syndrome admitted to our hospital in March 2023, and discuss them in combination with domestic and foreign literature. ResultsThe first symptom of the patient was nystagmus, and then the patient gradually appeared decreased vision and hearing, acanthosis nigricans, diabetes, hypertriglyceridemia, liver dysfunction, urinary protein, fatty liver, subclinical hypothyroidism, and candida albicans infectious vaginitis, etc.. The genetic results showed that there were two mutations in the ALMS1 gene, both of which were located in exon 8. The ALMS1 gene c.6316C>T(p.Gln2106Ter) heterozygous mutation was a nonsense mutation, resulting in the termination of protein coding at the 2 106th position of glutamine; ALMS1 gene c.4642_4658del(p.Arg1548Trpfs*4) heterozygous mutation, a frameshift mutation, resulted in the protein encoding arginine being replaced by tryptophan at the 1 548th position , and premature termination of the codon at position 3,which was ultimately diagnosed as Alstrom syndrome. This disease has been currently incurable and most treatments were symptomatic. ConclusionAlstrom syndrome is rare in clinical practice, with complex and diverse manifestations, which can easily lead to misdiagnosis and missed diagnosis. For diabetes patients with impaired vision and hearing, we should be alert to Alstrom syndrome, and carry out gene detection as early as possible to make a clear diagnosis and early intervention to improve the quality of life of patients. Related Articles | Metrics

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Analysis of plasma metabolites in sepsis in children OU Junbin, LIN Minxin, LI Xiaolin, LIU Yuling, LIANG Qiao. 2024, 16 (1):  42-46.  Abstract ( 68 )   PDF (1171KB) ( 15 )   Save ObjectiveTo find the differential metabolites in children with sepsis by analyzing the levels of serum metabolites.MethodsSerum samples were collected in 24h after admission from 37 children with early sepsis as the observation group, who were hospitalized in Zhongshan Boai Hospital from October 2019 to November 2021,and 38 healthy children were enrolled as the control group during the same period. The levels of 11 kinds of amino acids and 31 kinds of acylcarnitine in plasma were detected and the differences in serum metabolites were compared between two groups.ResultsPrincipal component analysis(PCA) and orthogonal partial least squares diseriminant analysis(OPLS-DA) showed that there was significantly different metabolic profiling of plasma amino acids and acylcarnitine between observation group and control group; in the analysis of amino acid, the levels of phenylalanine, valine, leucine and glycine were significantly increased; in the analysis of acylcarnitine, the levels of butyrylcarnitine and isovalerylcarnitine were significantly increased， while the levels of l-carnitine, myristoylcarnitine, palmitoylcarnitine, hexadecenoyl carnitine,octadecanoylcarnitine,octadecaenoylcarnitine and octadecadienoylcarnitine were significantly decreased.ConclusionThe differences in serum metabolites in children with sepsis is mainly associated with metabolic disorders, and there may be mitochondrial dysfunction, which can be used as biomarkers of sepsis in children. Related Articles | Metrics

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Clinical value of methemoglobin in early identification of gastrointestinal symptom-related infection in premature infants LIU Biao, ZHANG Guoqing. 2024, 16 (1):  46-50.  Abstract ( 70 )   PDF (1092KB) ( 14 )   Save ObjectiveTo investigate the value of methemoglobin(MetHb) in early identification of neonatal infection in premature infants with gastrointestinal symptoms at onset of the disease.MethodsPremature infants who were hospitalized in the NICU from September 2021 to August 2022,with gastrointestinal symptoms at onset were included in this study.All the participants were admitted to our hospital within 24 hours of onset.The related indicators such as C-reactive protein(CRP),serum amyloid A(SAA) and MetHb were measured before antibiotic therapy.MaxMetHb(%) was defined as the ratio of the highest MetHb to hemoglobin monitored during active disease.The CRP,SAA and MaxMetHb between infected and non-infected neonates were compared.The receiver operating characteristic(ROC) curve was used to evaluate the efficacy of those indicators in early identification of neonatal infection.ResultsAmong the 53 premature infants with gastrointestinal symptoms at onset,29 subjects were infected and the remaining 24 were non-infected.However,there was no significant difference in the gastrointestinal symptoms between those two groups,suggesting that gastrointestinal symptoms were not specific in premature infants with infection.Compared to those non-infected subjects,CRP,SAA,neutrophils%(Neu%) and MaxMetHb were significantly increased in those infected neonates,while the eosinophils% was significantly lower(all P<0.05).In addition,the fasting time,course of antibiotic use and special antibiotic use rate of infected neonates were significantly higher than those of the non-infected(all P<0.001).MaxMetHb could be used for the early identification of neonatal infection,with its optimal cut-off point being 1.6%,with sensitivity of 86.2%,specificity of 62.5%,and area under the curve(AUC) of 0.766,and 75.5%(40/53) subjects could be successfully identified.When combining CRP and Neu% with MaxMetHb,the sensitivity,specificity and AUC could be further improved up to 93.1%,87.5%,and 0.961,respectively,and 90.6% patients(48/53) could be successfully identified.ConclusionMaxMetHb,combined with CRP and Neu%,is considered to be a suitable indicator for early identification of neonatal infection for premature infants with gastrointestinal symptoms at onset. Related Articles | Metrics

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Clinical study on myocardial damage in children with late onset breast milk jaundice WANG Haiyan, ZHAO Juan. 2024, 16 (1):  51-54.  Abstract ( 65 )   PDF (1046KB) ( 13 )   Save ObjectiveTo explore the effect of late-onset breast milk jaundice on the myocardial cells of affected children and the clinical value of early intervention treatment.MethodsA retrospective review of 86 cases of late-onset breast milk jaundice admitted to our Pediatric Center from April 2020 to January 2022 was conducted.According to the bilirubin level,they were divided into mild and moderate-severe groups.Sixty full-term healthy newborns examined in the Children's Health Clinic of our hospital during the same period were selected as the control group.On the day of admission,blood samples were collected from the study group during the peak and subsidence periods of jaundice,and 2 to 3 mL of venous blood was taken to detect serum totalwere higher than those in the mild group and the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the levels of myocardial enzymes(CK,CK-MB) and cTnI between the mild group and the control group(P>0.05).During the subsidence period of jaundice,there was no statistically significant difference in the levels of myocardial enzymes(CK,CK-MB) and cTnI between the mild and moderate-severe groups and the control group(P>0.05).During the peak period of jaundice in the moderate-severe group,the detection rate of cTnI was 51.4%(18/35),which was significantly higher than the detection rates of CK and CK-MB［17.1%(6/35),25.7%(9/35)］,with statistically significant differences(P<0.05).ConclusionDetecting serum myocardial enzymes(CK,CK-MB) and cTnI can early identify myocardial damage in children with late-onset breast milk jaundice.The higher the serum bilirubin level,the more severe the myocardial damage,indicating that early intervention and treatment has certain clinical value. bilirubin,myocardial enzymes (CK,CK-MB),and cardiac troponin I (cTnI).The control group underwent routine testing of the above items,and the results were statistically analyzed.ResultsDuring the peak period of jaundice,the levels of myocardial enzymes(CK,CK-MB) and cTnI in the moderate-severe group  Related Articles | Metrics

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A study of the correlation between scoliosis and symptoms of tic disorder in children JIANG Yiming, HAN Cheng′en, LUO Guangzhi, ZHANG Baoqing. 2024, 16 (1):  54-57.  Abstract ( 63 )   PDF (1044KB) ( 170 )   Save ObjectiveTo explore the relationship between symptoms of tic disorder(TD) and scoliosis, and the relationship between tic severity and scoliosis in children.MethodsA total of 60 children diagnosed with TD in the Department of Pediatrics of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from July to November of 2022 were selected as the study subjects. According to whether the study subjects had neck, shoulder and trunk tic symptoms, they were divided into TD1 group(n=40,with neck, shoulder and trunk tics) and TD2 group(n=20,without neck, shoulder and trunk tics). After screening, a standing spine X-ray was performed and correlation of scoliosis with head, neck and trunk symptoms as well as with tic severity was analyzed.ResultsThere were 26 cases of scoliosis(65%) in TD1 group and 14 cases of no-scoliosis(35%);there were 5 cases of scoliosis(25%) and 15 cases of no-scoliosis(75%) in TD2 group. (1)The difference in scoliosis between the TD1 group and the TD2 group was statistically significant(P=0.003). (2)The results of multivariate logistic regression analysis showed that there was a statistically significant difference in the effect of scoliosis angle on tic severity (OR=1.16, 95%CI 1.04-1.30, P=0.01).ConclusionScoliosis is associated with symptoms of neck, shoulder and trunk tics, and scoliosis angle correlates with tic severity. Related Articles | Metrics

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Treatment experience in infantile anorexia with Tui Na LIANG Meng, CHEN Jingjing, ZUO Jinlan, ZHOU Tiqun, HU Limei, LENG Li. 2024, 16 (1):  58-62.  Abstract ( 83 )   PDF (1055KB) ( 242 )   Save ObjectiveAnorexia nervosa in children is a common pediatric condition, which usually manifests as a long-term decrease in appetite or even refusal to eat. Anorexia can lead to imbalance in growth and development and a series of systemic diseases. Therefore, the prevention and treatment of anorexia nervosa has become a hot topic in Chinese and Western pediatric researches. Tui Na is a method of treatment which promotes the circulation of Qi and blood and regulates Yin and Yang by stimulating acupoints with Yin-Yang and Five Elements and meridian theory as the theoretical basis and differentiated treatment as the principle. This article introduces the clinical thinking and acupoint selection experience of Mr. Wang Huiyao, former director of the Second Affiliated Hospital of Guiyang College of Traditional Chinese Medicine, in the treatment of anorexia nervosa in children with Tui Na. According to the primary etiology and pathogenesis of anorexia nervosa being "disharmony between spleen and stomach and loss of normal functioning of spleen", and based on years of experience in managing pediatric diseases and observation on children being unable to talk about their disease clearly, Prof. Wang uses the method of "running through up and down and regulation between before and after" in clinical selection of acupoints to promote the digestion, absorption, excretion and transfer function of spleen and stomach, in order to regulate Yin-Yang balance and organ functions, which achieves the purpose of stimulating the children's own potential and their self-healing ability and improving clinical effect in the treatment of anorexia nervosa. After decades of standardized research on pediatric Tui Na therapy for anorexia nervosa, through data mining and clinical selection of acupuncture points, he summarized the basic therapeutic prescription for anorexia nervosa, which better improves the efficacy of Tui Na therapy for anorexia nervosa and avoids the pain of acupuncture and medicine for children. Attached is a case study of anorexia nervosa in pediatricpatients treated with the basic formula of anorexia nervosa by Mr. Wang, which can be used for reference and discussion among colleagues so as to provide better service to the children. Related Articles | Metrics

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Observation on multi-directional stimulation acupuncture on ankle dorsiflexion function in patients with common peroneal  nerve injury HAN Meimei, DUAN Liyang, LYU Nan, SHANG Qing, SHI Liye. 2024, 16 (1):  62-65.  Abstract ( 75 )   PDF (1037KB) ( 51 )   Save 】ObjectiveTo compare the efficacy of multi-directional stimulation acupuncture and conventional acupuncture on common peroneal nerve injury.MethodsA retrospective cohort study was conducted to collect the clinical data of 40 children with common peroneal nerve injury admitted to the Rehabilitation Department of Henan Children′s Hospital from March 2018 to October 2022,and they were divided into a multi-directional stimulation acupuncture group and a conventional acupuncture group according to different treatment plans,with 20 cases in each group.Acupuncture points such as Yanglingquan,Zusanli,Sanyinjiao,Jiexi and Taichong were selected in both groups on the affected lower limbs.The multi-directional stimulation group was given multi-directional stimulation based on routine point selection,while the conventional acupuncture group was given the even needling.Both groups were treated once daily,5 days a week,4 weeks (20 times) for one course,and the therapeutic effect was evaluated after a total of 8 weeks(2 courses).The changes in dorsiflexion angle,the treatment effect and lower limb motor function were evaluated in the two groups.ResultsAfter treatment,the total effective rate of multi-directional stimulation acupuncture group was 90.0% (18/20),significantly higher than that of conventional acupuncture group(60.0%，12/20),and the difference was statistically significant (P<0.05).After treatment,the Fugl-Meyer motor function score and improvement degree of ankle dorsiflexion motion in the multi-directional stimulation acupuncture group were significantly higher than those in the conventional acupuncture group,and the difference was statistically significant(P<0.05).ConclusionThe treatment effect of multi-directional stimulation acupuncture is better than that of conventional acupuncture in improving lower limb motor function and ankle joint motion,which is worthy of clinical application. Related Articles | Metrics

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Curative effect of Kangmin Tongqiao decoction combined with Helium-Neon laser treatment on allergic rhinitis in children YANG Chuwen, ZHAO Jun, CUI Chen, SONG Qinli, LU Xiaoye, ZHOU Fangyuan. 2024, 16 (1):  66-71.  Abstract ( 88 )   PDF (1088KB) ( 113 )   Save ObjectiveTo verify the clinical efficacy of Kangmin Tongqiao decoction combined with Helium-Neon laser in children with allergic rhinitis.MethodsTotally 104 children aged 3 to 14 years meeting the diagnostic criteria for allergic rhinitis treated in our hospital from Jan. 2022 to Jan. 2023 were randomly divided into treatment group and control group, with 52 children in each group. Both of them routinely use physiological seawater to flush the nasal cavity as the basic treatment. The treatment group was treated with Kangmin Tongqiao decoction combined with Helium-Neon laser, and the control group was treated with Helium-Neon laser. After 2 weeks of treatment, the clinical efficacy, clinical symptom score, absolute value of peripheral blood eosinophil count, percentage of eosinophils and total serum IgE level were observed, and the improvement in score of life quality questionnaire, sleep quality and anxiety status were compared between the two groups.ResultsThe total response rate of the treatment and control groups was 100.0%(52/52) and 61.54%(32/52), respectively, the difference being statistically significant(P<0.05). After treatment, the clinical symptom score, peripheral blood eosinophil count, blood eosinophil percentage, total IgE, score of life quality questionnaire, sleep quality score, and anxiety score were significantly lower, while the clinical symptom score, peripheral blood eosinophil count, blood eosinophil percentage, score of life quality questionnaire, and anxiety score of treatment group were significantly lower than those of the control group(P<0.05).ConclusionKangmin Tongqiao decoction combined with Helium-Neon laser has significant effect on allergic rhinitis, which can significantly improve the quality of life, sleep quality and anxiety in children. Related Articles | Metrics

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Professor Wang Xuefeng's experience in treating refractory nephritic syndrome combined with atopic dermatitis in children SHEN Xiaoyu, WANG Cuijin, WU Yan, YIN Lei, SUN Kexing, SHA Sha, WANG Xuefeng. 2024, 16 (1):  72-76.  Abstract ( 65 )   PDF (1055KB) ( 217 )   Save Refractory nephrotic syndrome(RNS) is difficult to treat and has a high recurrence rate. Modern research has found that patients are often accompanied by an increase in total IgE in peripheral blood, which has many similarities with atopic diseases. It is speculated that the pathogenesis and cytokine changes are similar between RNS and atopic dermatitis(AD). The clinical treatment for RNS combined with AD is more challenging. Professor Wang Xuefeng, based on the theory of the Huangdi Inner Canon, proposes that there are three phases of "powerful fire inside", "powerful fire consuming qi" and "junior fire insufficiency" in the corticosteroid therapy for RNS. She believes that the key pathogenesis of steroid-dependent(SDNS) and frequently relapsing nephrotic syndrome(FRNS) is "powerful fire consuming qi", and the focus in the treatment of SDNS/FRNS is to maintain the function of junior fire generating qi, and to reduce the side effects of "powerful fire consuming qi", so as to prevent steroid dependence and frequent recurrence. Also, RNS combined with AD is different fromcommon sores and furuncles; it is Yin deficiency, body weakness and toxin strength. After the lesion is removed, the toxin has not gone and Yin becomes less, so the disease is difficult to heal. Professor Wang Xuefeng emphasizes that different medications should be used for different stages of NS, and she pays attention to Qi nourishing and Yin nourishing, which had a good clinical effect.  Related Articles | Metrics

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Common pair medicines in differentiated treatment for childhood obesity JIANG Jinwen, ZHANG Xuerong, DUAN Yunyan, DENG Lihua 2024, 16 (1):  76-79.  Abstract ( 75 )   PDF (1035KB) ( 18 )   Save This is to summarize Professor Zhang Xuerong's experience in the use of pair medicines in the treatment of childhood obesity.Professor Zhang believes that the disease position of childhood obesity is mainly in the spleen,often involving the liver and kidneys,and the basic pathogenesis is spleen deficiency and dampness,and has liver depression or kidney yang deficiency,causing phlegm and stasis and blood endogenous retention in muscles and tissues,which results in obesity.It belongs to deficiency in origin and excess in superficiality.The treatment should strengthening the spleen and removing dampness,supplemented by relieving liver,focus on nourishing kidney yang,resolving phlegm and activating blood.Commonly used pair medicines include lotus leaves and zeppelin,poria cocos and atractylodes,Chaihu and citron,salvia and Chuanxiong,Fushen and acacia skin,and smilax glabra and Weilingxian.The pair medicines are properly matched and the effect is obvious.One case is attached for verification. Related Articles | Metrics

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Study on medication rules in the treatment of eczema and atopic dermatitis based on national patent Chinese herbal compound prescriptions SHAO Lingyang, WANG Hai 2024, 16 (1):  80-84.  Abstract ( 106 )   PDF (1622KB) ( 78 )   Save ObjectiveTo analyze the medication rules of national patent Chinese herbal compound prescriptions for eczema and atopic dermatitis based on data mining in order to direct the development of new medicines and basic researches.MethodsWe searched for Chinese herbal compound patents for the treatment of eczema and atopic dermatitis in the State Intellectual Property Office's patent database, and we statistically analyzed those patents using the bibliometric approach, data mining analysis, association rule analysis, etc.. Using the TCM Heritage Assist Platform V2.5, we created association rule network diagrams using SPSS Modeler 18.0 and made cluster analysis using SPSS 26.0.ResultsThis study examined 380 herbal medicines used in a total of 425 internal Chinese herbal compound formulas for the treatment of eczema and atopic dermatitis. All of the medicines were bitter and cold in nature, with Kushen, Difuzi, Huangbai and Baixianpi serving as the main ingredients; the majority of them functioned through the liver, stomach, lung, and spleen meridians. Further investigation into potential new prescriptions was made.ConclusionThe fundamental principle of "clearing heat and dampness, dispelling wind and relieving itch" is summarized as the main principle of clinical application of TCM for eczema and atopic dermatitis, and data mining provides new theoretical foundation for clinical prevention and therapy. Related Articles | Metrics

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Analysis of experience in the treatment of children with mesenteric lymphadenitis (type of deficiency and coldness of spleen and stomach) LI Peiqiong, SUN Liping. 2024, 16 (1):  85-88.  Abstract ( 82 )   PDF (1032KB) ( 164 )   Save To discuss Professor Sun Liping's clinical experience in treating pediatric mesenteric lymphadenitis. Professor Sun Liping believes that the disease is concerned with the spleen and stomach; the internal cause is the deficiency of spleen and insufficiency of pediatric-yang, and the external cause is the injury caused by cold weather, excessive consumption of cold food and medicine. The disease is treated in two phases: the exacerbation phase and the remission phase. In the exacerbation phase, the treatment principle is to soften hard masses and resolve stagnation, and to warm the spleen and stomach and stop pain; it is advisable to use Tianzhu powder with modification to eliminate and supplement, mainly to eliminate. In the remission phase, the treatment principle is to replenish the spleen and strengthen qi, and to warm the spleen and stomach and tonify deficiency, with tonification being the mainstay; it is advisable to use Shenling Baizhu powder with modification. Related Articles | Metrics

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A brief analysis of the pathogenesis and syndrome differentiation of autism spectrum disorders from the "brain-spleen and kidney correlation" CHEN Xi, PENG Yaqi, LI Wei, YANG Hongsheng, WANG Junhong. 2024, 16 (1):  88-92.  Abstract ( 115 )   PDF (1055KB) ( 576 )   Save Autism spectrum disorders(ASD) is characterized by sustained impaired social ability, repetitive behaviors or interests, and stereotyped behavior. It is a common pediatric neuropsychiatric disease with great harm in TCM pediatrics, and in 2020, the domestic incidence has reached 7‰. The optimal treatment period is often missed due to delayed diagnosis, limited treatment measures, failure to adhere to treatment, improper parental care and so on. The "Original Spirit" of ASD is damaged, and the lesion is in the brain. This paper analyzes the correlation between brain and spleen and kidney from the material basis, structural basis, operational basis and pathological connection, and concludes that the deficiency of spleen and kidney is the fundamental pathogenesis of ASD, and phlegm and blood stasis is the important pathological factors of ASD. Professor Wang Junhong thinks that the physiological and pathological characteristics of children should be considered clinically, and the basic treatment should be to tonify the kidney and spleen, eliminate phlegm and remove blood stasis. At the same time, there should be no improper tonification, and the focus is to regulate the whole body movement and chemical function of children. In the treatment, the classic prescription Liuwei Dihuang pills and Liujunzi decoction are selected as the main prescription of Bushen Yunpi Yizhi prescription. According to the viscus syndrome, the treatment combines comprehensive analysis of the four examination methods and achieves good effects. Based on clinical cases, this article introduces the key points of syndrome differentiation, treatment and medication experience of Bushen Yunpi Yizhi prescription in the treatment of children with ASD. Related Articles | Metrics